Endocrine Abstracts

Data from the literature suggest that endogenous Cushing’s syndrome (CS) is an unusual disorder in the general population with a reported incidence of 2–3 cases per 1 million inhabitants per year. Patients who are not cured from CS have a poor prognosis with an increased mortality due to cardiovascular disease and significant morbidity that impairs quality of life. Recently published screening studies performed in obese patients with type 2 diabetes or patients with ...

Isolated acquired hypoaldosteronism (HA) is considered to be a cause of hypovolemic hyponatremia (HH) with urinary sodium loss (UNaL) and hyperkalemia/upper-limit serum potassium (SK). However, some authors question the presentation of hyponatremia of these characteristics in the absence of Addison’s disease (AD).We present a series of patients with HA. Methods: Aretrospective study of 70 cases of HH with UNaL (UNa > 25 mmol/l) and SK ≥ 5 mmol/l or in...

Introduction: Resistance to thyroid hormones (RTH) is a genetic disorder caused in 85% of cases by mutations in thyroid hormone receptor beta gene (TRβ). The current information about it in Spanish population is scarce, limited to case reports or short series of patients. Thus, we aimed to describe the clinical, biochemical and genetic features of Mediterranean patients with RTH referred to our institution (one of the referral centres in Spain) for genetic testing during ...